Atıf İçin Kopyala
Salzer E., KANSU TANCA A., Sic H., Majek P., İKİNCİOĞULLARI K. A., DOĞU E. F., ...Daha Fazla
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, cilt.133, sa.6, ss.1651-1671, 2014 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
133
Sayı:
6
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Basım Tarihi:
2014
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Doi Numarası:
10.1016/j.jaci.2014.02.034
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Dergi Adı:
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.1651-1671
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Anahtar Kelimeler:
IL-21, early-onset inflammatory bowel disease, common variable immunodeficiency, exome sequencing, RENAL-CELL CARCINOMA, INTERLEUKIN-21 RECEPTOR, METASTATIC MELANOMA, NK CELLS, B-CELLS, PHASE-I, MATURATION, MUTATIONS, PROTEIN, IMMUNOGLOBULIN
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Ankara Üniversitesi Adresli:
Evet
Özet
Background: Alterations of immune homeostasis in the gut can result in development of inflammatory bowel disease (IBD). Recently, Mendelian forms of IBD have been discovered, as exemplified by deficiency of IL-10 or its receptor subunits. In addition, other types of primary immunodeficiency disorders might be associated with intestinal inflammation as one of their leading clinical presentations.