Clinical applications of decellularized extracellular matrices for tissue engineering and regenerative medicine

Parmaksız M., Dogan A., Odabaş S., Elçin A. E., Elçin Y. M.

BIOMEDICAL MATERIALS, cilt.11, sa.2, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 11 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1088/1748-6041/11/2/022003
  • Dergi Adı: BIOMEDICAL MATERIALS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Anahtar Kelimeler: decellularization, extracellular matrix (ECM), clinical applications, biomaterials, tissue engineering, regenerative medicine, DEMINERALIZED BONE-MATRIX, ACELLULAR DERMAL MATRIX, TENDON AUGMENTATION GRAFTS, SMALL-INTESTINAL SUBMUCOSA, STEM-CELL DIFFERENTIATION, PORCINE MEDIAL MENISCUS, VOLUMETRIC MUSCLE LOSS, IN-VITRO, BREAST RECONSTRUCTION, SKELETAL-MUSCLE
  • Ankara Üniversitesi Adresli: Evet

Özet

Decellularization is the process of removing the cellular components from tissues or organs. It is a promising technology for obtaining a biomaterial with a highly preserved extracellular matrix (ECM), which may also act as a biological scaffold for tissue engineering and regenerative therapies. Decellularized products are gaining clinical importance and market space due to their ease of standardized production, constant availability for grafting and mechanical or biochemical superiority against competing clinical options, yielding clinical results ahead of the ones with autografts in some applications. Current drawbacks and limitations of traditional treatments and clinical applications can be overcome by using decellularized or acellular matrices. Several companies are leading the market with versatile acellular products designed for diverse use in the reconstruction of tissues and organs. This review describes ECM-based decellularized and acellular products that are currently in use for different branches of clinic.