Evaluation of dietary inflammatory index and dietary antioxidant capacity with maternal inflammatory and oxidative markers in preeclampsia

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Gezer I. S., Bastemur A. G., Tanacan A., Karagoz C., Kesikli B., Kara O., ...Daha Fazla

NUTRIRE, cilt.51, ss.51-100, 2026 (ESCI)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 51
  • Basım Tarihi: 2026
  • Doi Numarası: 10.1186/s41110-026-00517-9
  • Dergi Adı: NUTRIRE
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
  • Sayfa Sayıları: ss.51-100
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Abstract

Purpose

This study aimed to investigate the potential association between maternal nutritional intakes, Dietary Inflammatory Index (DII), dietary total antioxidant capacity, maternal serum inflammation, and oxidative markers in preeclampsia. 

Methods

In this prospective case-control study, a total of 53 pregnant women (23 with preeclampsia and 30 normotensive pregnant women as controls) in their third trimester were included. Dietary intake was assessed via dietary recalls, analyzed through standardized databases. Maternal E-DII (Energy-Adjusted Dietary Inflammatory Index), dietary antioxidant capacity (dORAC), serum interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), total antioxidant status (TAS), and total oxidant status (TOS) were measured. 

Results

The main findings of this study were significantly elevated E-DII (p<0.001) and decreased ORAC (p<0.01) levels. Women with preeclampsia had a diet significantly low in protein, plant-derived proteins, overall fat, energy, carbohydrates, fiber, and omega-3 intake. There was a positive correlation between serum TNF-α and E-DII (p=0.016, r=0.329) and a significant negative correlation between E-DII and dORAC (r=-.526, p<0.001). Maternal serum TNF-α levels were significantly elevated (p<0.01), and IL-10 levels significantly decreased in preeclampsia (p<0.001).

Conclusion

The findings emphasize the potential role of antioxidants and the inflammatory potential of nutrition on maternal inflammation and oxidative parameters in relation to preeclampsia risk and support the importance of nutritional follow-up during pregnancy.