Detection of the SRY gene in patients with Turner Syndrome

Kurnaz E., Cetinkaya S., Savas-Erdeve S., AYCAN Z.

JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, cilt.48, sa.4, ss.265-267, 2019 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 48 Sayı: 4
  • Basım Tarihi: 2019
  • Doi Numarası: 10.1016/j.jogoh.2019.01.012
  • Dergi Adı: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.265-267
  • Anahtar Kelimeler: Sex determination, Turner syndrome, Gonadoblastoma, Reproductive endocrinology, Y-CHROMOSOME SEQUENCES, 45,X KARYOTYPE, MOSAICISM, PCR, GONADOBLASTOMA, IDENTIFICATION, GONADS, ORIGIN, RISK
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: If turner syndrome (TS) patients have a Y-containing cell line, they have an increased risk for gonadal tumors. TS patients are therefore screened for Y-chromosome and Y-specific sequences, such as SRY, DYZI, DYZ3, DYS132, ZFY, TSPY, etc. In addition, since the dysgenetic gonad may include the stroma and granulosa/sertoli cells, which produce androgens, virilization can seen in girls with Y-chromosomal material. Prophylactic gonadectomy may therefore be required for optimal management in such patients. Our aim is to discuss our observations in the follow-up of TS patients.