Detection of the SRY gene in patients with Turner Syndrome
JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION, cilt.48, sa.4, ss.265-267, 2019 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 48 Sayı: 4
- Basım Tarihi: 2019
- Doi Numarası: 10.1016/j.jogoh.2019.01.012
- Dergi Adı: JOURNAL OF GYNECOLOGY OBSTETRICS AND HUMAN REPRODUCTION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.265-267
- Anahtar Kelimeler: Sex determination, Turner syndrome, Gonadoblastoma, Reproductive endocrinology, Y-CHROMOSOME SEQUENCES, 45,X KARYOTYPE, MOSAICISM, PCR, GONADOBLASTOMA, IDENTIFICATION, GONADS, ORIGIN, RISK
- Ankara Üniversitesi Adresli: Evet
Özet
Background: If turner syndrome (TS) patients have a Y-containing cell line, they have an increased risk for gonadal tumors. TS patients are therefore screened for Y-chromosome and Y-specific sequences, such as SRY, DYZI, DYZ3, DYS132, ZFY, TSPY, etc. In addition, since the dysgenetic gonad may include the stroma and granulosa/sertoli cells, which produce androgens, virilization can seen in girls with Y-chromosomal material. Prophylactic gonadectomy may therefore be required for optimal management in such patients. Our aim is to discuss our observations in the follow-up of TS patients.