The effects of gentamicin on the activities of glutathione peroxidase and superoxide dismutase enzymes and malondialdehyde levels in heart tissues of guinea pigs

ÖZTÜRK H. S., Kavutcu M., Kacmaz M., CANBOLAT O., Durak I.

CURRENT MEDICAL RESEARCH AND OPINION, cilt.14, sa.1, ss.47-52, 1997 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 14 Sayı: 1
  • Basım Tarihi: 1997
  • Doi Numarası: 10.1185/03007999709113342
  • Dergi Adı: CURRENT MEDICAL RESEARCH AND OPINION
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.47-52
  • Anahtar Kelimeler: gentamicin, free radicals, vitamin E, heart, FREE-RADICAL SCAVENGERS, RAT RENAL CORTEX, LIPID-PEROXIDATION, REPERFUSION INJURY, MYOCARDIAL INJURY, INFARCT SIZE, REDUCTION, ISCHEMIA, TOXICITY, CATALASE
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities and malondialdehyde (MDA) levels were measured in heart tissues from guinea pigs treated with gentamicin and gentamicin plus vitamin E combination. Mean values were compared with those of the controls treated with only physiological saline solution. The activities of SOD and GSH-Px were found to be lower and the MDA level higher in the hearts from gentamicin-treated animals compared with those of the controls. In the gentamicin plus vitamin E group, however, tissue SOD activity was found to be increased and MDA level decreased significantly relative to the gentamicin group. GSH-Px activity was lowest in this group.