Short overview on the relevance of microRNA-reactive oxygen species (ROS) interactions and lipid peroxidation for modulation of oxidative stress-mediated signalling pathways in cancer treatment

ÜLKER Ö., Panieri E., SÜZEN S., Jaganjac M., Zarkovic N., Saso L.

JOURNAL OF PHARMACY AND PHARMACOLOGY, cilt.74, sa.4, ss.503-515, 2022 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 74 Sayı: 4
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1093/jpp/rgab045
  • Dergi Adı: JOURNAL OF PHARMACY AND PHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, Aquatic Science & Fisheries Abstracts (ASFA), BIOSIS, Biotechnology Research Abstracts, CAB Abstracts, Chemical Abstracts Core, EMBASE, International Pharmaceutical Abstracts, MEDLINE, Veterinary Science Database
  • Sayfa Sayıları: ss.503-515
  • Anahtar Kelimeler: tissue and cellular pharmacology, molecular and clinical pharmacology, drug discovery and characterization, drugs from natural sources, molecular and receptor pharmacology, molecular and clinical pharmacology, FACTOR-KAPPA-B, COLORECTAL-CANCER, CELL-DEATH, CISPLATIN RESISTANCE, EMERGING ROLE, IN-VITRO, APOPTOSIS, FERROPTOSIS, INHIBITOR, MECHANISMS
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives Modulation of oxidative stress-mediated signalling pathways is constantly getting more attention as a valuable therapeutic strategy in cancer treatment. Although complexity of redox signalling pathways might represent a major hurdle, the development of advanced -omics technologies allow thorough studies on cancer-specific biology, which is essential to elucidate the impact of these signalling pathways in cancer cells. The scope of our review is to provide updated information about recent developments in cancer treatment. Key findings In recent years identifying oxidative stress-mediated signalling pathways is a major goal of cancer research assuming it may provide novel therapeutic approaches through the development of agents that may have better tissue penetration and therefore affect specific redox signalling pathways. In this review, we discuss some recent studies focussed on the modulation of oxidative stress-related signalling pathways as a novel anti-cancer treatment, with a particular emphasis on the induction of lipid peroxidation. Conclusions Characterization and modulation of oxidative stress-mediated signalling pathways and lipid peroxidation products will continue to foster novel interest and further investigations, which may pave the way for more effective, selective, and personalized integrative biomedicine treatment strategies.