T-ALL with monoclonal gammopathy and hairy cell features

Yetgin S., Olcay L., Yel L., Tuncer M., Tezcan I., Erdemli E., ...More

AMERICAN JOURNAL OF HEMATOLOGY, vol.65, no.2, pp.166-170, 2000 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 65 Issue: 2
  • Publication Date: 2000
  • Journal Name: AMERICAN JOURNAL OF HEMATOLOGY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.166-170
  • Keywords: T-ALL, hairy cell leukemia, monoclonal gammopathy, LEUKEMIA, IMMUNOGLOBULIN, REARRANGEMENT, VARIANT, JAPANESE, GENES, ALPHA, HCL
  • Ankara University Affiliated: Yes

Abstract

The presented case is a boy with T-cell acute lymphoblastic leukemia (ALL) with hairy cell (HC) features and monoclonal gammopathy, The disease process had an acute onset and followed a rapid, progressive course. The patient had minimal splenomegaly and bicytopenia, but the bone marrow displayed increased numbers of reticulin fibers. The blasts were positive for tartrate-resistant acid phosphatase (TRAP) and CD11c, Molecular analysis revealed rearrangement of immunoglobulin heavy chain genes and a rearranged T-cell receptor (TcR beta) beta gene. The patient responded to conventional ALL therapy. Acute T-cell ALL with HC features in childhood has not been reported previously, either alone or in association with monoclonal gammopathy, We propose "T-ALL with hairy cell features" to describe this case. (C) 2000 Wiley-Liss, Inc.