The relationship between angiotensin converting enzyme gene I/D polymorphism and QT dispersion in patients with hypertrophic cardiomyopathy

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TULUNAY KAYA C., Gurlek A., Altin T., Kilickap M., KARABULUT H. G., Turhan S., ...Daha Fazla

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, cilt.11, sa.3, ss.192-197, 2010 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 11 Sayı: 3
  • Basım Tarihi: 2010
  • Doi Numarası: 10.1177/1470320310368190
  • Dergi Adı: JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.192-197
  • Anahtar Kelimeler: ACE gene I/D polymorphism, arrhythmia, corrected QT dispersion, hypertrophic cardiomyopathy, QT dispersion, LEFT-VENTRICULAR HYPERTROPHY, INSERTION DELETION POLYMORPHISM, ABNORMALITIES, ENHANCEMENT, ARRHYTHMIAS, MORTALITY, GENOTYPE, INTERVAL, DISEASE, DEATH
  • Ankara Üniversitesi Adresli: Evet

Özet

Introduction: Hypertrophic cardiomyopathy (HCM) is characterized by disorganized myocardial architecture, and may cause ventricular arrhythmias and sudden death. The angiotensin-converting enzyme (ACE) with two deletion alleles (DD genotype) has been proposed to be associated with increased myocardial collagen content. We evaluated QT dispersion (QTd), which reflects regional differences in ventricular repolarization, in HCM patient and controls among the three different ACE genotypes.