Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells

Bulbula M. V., Ozbek H., Acıkara O. B., Ozbilgin S., Oz B., Kurtul E., ...Daha Fazla

Journal of Experimental and Clinical Medicine (Turkey), cilt.35, sa.4, ss.101-109, 2018 (Scopus)

Özet

© 2018 OMUIn this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated. With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified. In continuation of the study; the antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells were evaluated by Caspase 3, Annexin V / PI Apoptosis / Necrosis analysis, Apopxin Green and 7-AAD Apoptosis / Necrosis analysis. The antiproliferative, apoptotic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined.