Antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells

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Atıf İçin Kopyala

Bulbula M. V., Ozbek H., Acıkara O. B., Ozbilgin S., Oz B., Kurtul E., ...Daha Fazla

Journal of Experimental and Clinical Medicine (Turkey), cilt.35, sa.4, ss.101-109, 2018 (Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 35 Sayı: 4
• Basım Tarihi: 2018
• Doi Numarası: 10.5835/jecm.omu.35.04.003
• Dergi Adı: Journal of Experimental and Clinical Medicine (Turkey)
• Derginin Tarandığı İndeksler: Scopus
• Sayfa Sayıları: ss.101-109
• Anahtar Kelimeler: Apoptosis Flow cytometry HCT-116 HEK-293 Necrosis
• Ankara Üniversitesi Adresli: Evet

Özet

© 2018 OMUIn this study, the cytotoxic effects of the extracts of methanol: water (80:20) prepared from the above-ground parts of the varieties of Onobrychis albiflora Hub.-Mor., Onobrychis argyrea Boiss. subsp. argyrea, Onobrychis galegifolia Boiss. and Onobrychis tournefortii (Willd.) Desv. species to HCT-116 cells were investigated. With cytotoxicity analysis that with these species inhibitor concentrations (IC50) which resulted in a 50% reduction in the proliferation of HCT-116 cells were identified. In continuation of the study; the antiproliferative and apoptotic effects of Onobrychis albiflora extract on HCT-116 cells were evaluated by Caspase 3, Annexin V / PI Apoptosis / Necrosis analysis, Apopxin Green and 7-AAD Apoptosis / Necrosis analysis. The antiproliferative, apoptotic and necrotic effects of Onobrychis albiflora extract on HCT-116 cells also were determined.