A chemometric optimization of method for determination of nitrosamines in gastric juices by GC-MS

AKYÜZ M., ATA Ş., DİNÇ E.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, cilt.117, ss.26-36, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 117
  • Basım Tarihi: 2016
  • Doi Numarası: 10.1016/j.jpba.2015.08.021
  • Dergi Adı: JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.26-36
  • Anahtar Kelimeler: Nitrosamines, Chemometric, GC-MS, Gastric juices, Diseases, VOLATILE N-NITROSAMINES, CHROMATOGRAPHY-MASS-SPECTROMETRY, PRESSURE CHEMICAL-IONIZATION, LIQUID-CHROMATOGRAPHY, GAS-CHROMATOGRAPHY, NITROSO COMPOUNDS, CANCER, EXPOSURE, LIVER, FOOD
  • Ankara Üniversitesi Adresli: Evet

Özet

A chemometrically optimized isolation procedure combined with gas chromatography-mass spectrometry detection technique has been proposed for quantitative determination of trace levels of nitrosamines in gastric juice samples of patients with the gastrointestinal tract problems. The extraction conditions of each nitrosamine were optimized using regression modelling based on central composite design. The extraction conditions for all nitrosamines were selected to be 10.7 min for extraction time, 4.2 for pH and 23 for 2-propanol percentage in extraction solution.