Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms

AKBULUT, HAKAN; Tang, YC; Maynard, J; Zhang, LX; Pizzorno, G; Deisseroth, A

doi:10.1158/1078-0432.ccr-04-0490

Vector targeting makes 5-fluorouracil chemotherapy less toxic and more effective in animal models of epithelial neoplasms

AKBULUT H., Tang Y., Maynard J., Zhang L., Pizzorno G., Deisseroth A.

CLINICAL CANCER RESEARCH, cilt.10, sa.22, ss.7738-7746, 2004 (SCI-Expanded, Scopus)

Yayın Türü: Makale / Tam Makale
Cilt numarası: 10 Sayı: 22
Basım Tarihi: 2004
Doi Numarası: 10.1158/1078-0432.ccr-04-0490
Dergi Adı: CLINICAL CANCER RESEARCH
Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Sayfa Sayıları: ss.7738-7746
Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
Ankara Üniversitesi Adresli: Evet

Özet

Purpose: 5-Fluorouracil (5-FU) has been combined in the past with other drugs for the combination chemotherapy for cancers of the breast, ovary, and colon. These drug regimens were limited by the fact that 5-FU fails to kill nondividing cancer cells at the doses that are safe to deliver. The goal of the present study is to test the feasibility of replacing 5-FU in established 5-FU combination chemotherapy with the Ad-LpCDIRESE1A/5-fluorocytosine (5-FC) system for the purpose of reducing toxicity and increasing efficacy.