Serum Transforming Growth Factor-beta (TGF-beta), Matrix Metalloproteinase-2 (MMP-2), Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitors of Metalloproteinase (TIMP-1) Levels in Childhood Asthma

DOĞU E. F., Yildiran A., Guloglu D., Cipe F. E., Yuksek M., Babacan E., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.38, no.5, pp.415-419, 2008 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Publication Type: Article / Article
  • Volume: 38 Issue: 5
  • Publication Date: 2008
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.415-419
  • Keywords: Asthma, children, metalloproteinase, airway remodelling, AIRWAY INFLAMMATION, CHILDREN, CELLS
  • Ankara University Affiliated: Yes

Abstract

Aims: Airway remodelling is a characteristic feature of asthma and is a dynamic process involving extracellular matrix (ECM) production and its degradation. In this regard, the matrix metalloproteinases (MMPs) and their specific inhibitors known as tissue inhibitors of metalloproteinases (TIMPs) have been shown to be important in this process. In the present study, transforming growth factor (TGF)-beta. MMP-2, MMP-9 and TIMP-1 levels in serum samples of children with stable asthma and healthy controls were evaluated to determine whether these levels show any difference between asthmatic and healthy children and whether or not these levels change with atopic status.