Serum Transforming Growth Factor-beta (TGF-beta), Matrix Metalloproteinase-2 (MMP-2), Matrix Metalloproteinase-9 (MMP-9) and Tissue Inhibitors of Metalloproteinase (TIMP-1) Levels in Childhood Asthma

DOĞU E. F., Yildiran A., Guloglu D., Cipe F. E., Yuksek M., Babacan E., ...Daha Fazla

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.38, sa.5, ss.415-419, 2008 (SCI-Expanded, Scopus, TRDizin) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 38 Sayı: 5
  • Basım Tarihi: 2008
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.415-419
  • Anahtar Kelimeler: Asthma, children, metalloproteinase, airway remodelling, AIRWAY INFLAMMATION, CHILDREN, CELLS
  • Ankara Üniversitesi Adresli: Evet

Özet

Aims: Airway remodelling is a characteristic feature of asthma and is a dynamic process involving extracellular matrix (ECM) production and its degradation. In this regard, the matrix metalloproteinases (MMPs) and their specific inhibitors known as tissue inhibitors of metalloproteinases (TIMPs) have been shown to be important in this process. In the present study, transforming growth factor (TGF)-beta. MMP-2, MMP-9 and TIMP-1 levels in serum samples of children with stable asthma and healthy controls were evaluated to determine whether these levels show any difference between asthmatic and healthy children and whether or not these levels change with atopic status.