Default mode network connectivity differences in obsessive-compulsive disorder

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Koçak O. M., Kale E., ÇİÇEK M.

Activitas Nervosa Superior, cilt.54, sa.3-4, ss.118-124, 2012 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 54 Sayı: 3-4
  • Basım Tarihi: 2012
  • Doi Numarası: 10.1007/bf03379589
  • Dergi Adı: Activitas Nervosa Superior
  • Derginin Tarandığı İndeksler: Scopus, Academic Search Premier, EMBASE
  • Sayfa Sayıları: ss.118-124
  • Anahtar Kelimeler: fMRI, Functional connectivity, Obsessive-compulsive disorder, Resting activity
  • Ankara Üniversitesi Adresli: Evet

Özet

Recent evidence suggests that the brain intrinsic activity during rest might be as significant as task evoked activities and consumes considerable energy linked to neural signaling processes. We performed an fMRI study recently aiming to compare the differences in brain activity between patients with obsessive-compulsive disorder and healthy volunteers during a simple suppression paradigm. We hypothesized that the patients with obsessive-compulsive disorder would show default mode network (DMN) connectivity dissociations from healthy individuals. OCD patients had higher connectivity (p < 0.05) than controls between right inferior parietal lobe (IPL) and left ventral medial prefrontal cortex (MPFC).