Diagnostic Accuracy of 68Ga-DOTATATE PET/CT in Pulmonary Lesions: A Single-Center Retrospective Study


Dursun Ş., Akkuş Gündüz P., Turan Ş. N., Kılıç A., Yenigün B. M., Yüksel C., ...Daha Fazla

34th Annual Meeting of Asian Society for Cardiovascular and Thoracic Surgery, Antalya, Türkiye, 15 - 19 Nisan 2026, ss.7, (Özet Bildiri)

  • Yayın Türü: Bildiri / Özet Bildiri
  • Basıldığı Şehir: Antalya
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.7
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective:

Pulmonary carcinoid tumors (PCTs) are rare neuroendocrine neoplasms of the lung, and their

preoperative diagnosis often remains challenging. Thoracic computed tomography (CT)

frequently demonstrates non-specific findings, resulting in limited diagnostic accuracy. ⁶⁸Ga-

DOTATATE positron emission tomography/computed tomography (⁶⁸Ga-PET/CT), which

targets somatostatin receptors, has emerged as a promising imaging modality for neuroendocrine

tumors. This study aimed to evaluate the diagnostic performance of ⁶⁸Ga-PET/CT in PCTs.

Methods:

In this single-center, retrospective study, 39 patients who underwent ⁶⁸Ga-PET/CT and had

histopathologically confirmed diagnoses were included. Patients were classified into three

groups according to histopathology: PCTs, benign lesions, and other pulmonary malignancies.

Quantitative ⁶⁸Ga-PET/CT parameters, including SUVmax, SUVmean, metabolic tumor volume

(MTV), total lesion glycolysis (TLG), and molecular–morphologic volume ratio (MMVR), were

statistically compared among the groups using the Kruskal–Wallis test. A p value < 0.05 was

considered statistically significant.

Results:

Of the 39 patients, 23 (59%) were diagnosed with PCTs, 13 with benign lesions, and 3 with other

pulmonary malignancies. SUVmax, SUVmean, and TLG values on ⁶⁸Ga-PET/CT were

significantly higher in the PCT group compared with the other two groups (p < 0.01, p < 0.01,

and p = 0.01, respectively). Clinicopathological characteristics according to study groups are

presented in Table 1.

Conclusion:

⁶⁸Ga PET/CT demonstrates high diagnostic discrimination for PCTs, with significantly elevated

quantitative PET parameters compared with benign and other malignant pulmonary lesions.

These findings support the use of ⁶⁸Ga-PET/CT as a valuable imaging modality in th