A Novel Genotyping Method for Detection of the Muscarinic Receptor M1 Gene rs2067477 Polymorphism and Its Genotype/Allele Frequencies in a Turkish Population

Ozdemir F., Kir Y., TOK K. C., BASKAK B., SÜZEN H. S.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, sa.6, ss.653-658, 2020 (ESCI) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 17 Sayı: 6
  • Basım Tarihi: 2020
  • Doi Numarası: 10.4274/tjps.galenos.2019.46793
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.653-658
  • Anahtar Kelimeler: CHRM1, C267A, Turkish, schizophrenia, PCR-RFLP, VARIANT, SCHIZOPHRENIA, EPIDEMIOLOGY, EXPRESSION, COGNITION
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: Gene variation in the cholinergic muscarinic receptor 1 (CHRM1) has potential to become a candidate biomarker in the development of several disorders as well as drug response. In this study, a novel polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was developed to determine the C to A single nucleotide polymorphism at position 267 in the CHRM1 gene.