A Novel Genotyping Method for Detection of the Muscarinic Receptor M1 Gene rs2067477 Polymorphism and Its Genotype/Allele Frequencies in a Turkish Population

Ozdemir F., Kir Y., TOK K. C., BASKAK B., SÜZEN H. S.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, vol.17, no.6, pp.653-658, 2020 (ESCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 17 Issue: 6
  • Publication Date: 2020
  • Doi Number: 10.4274/tjps.galenos.2019.46793
  • Journal Name: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Journal Indexes: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.653-658
  • Keywords: CHRM1, C267A, Turkish, schizophrenia, PCR-RFLP, VARIANT, SCHIZOPHRENIA, EPIDEMIOLOGY, EXPRESSION, COGNITION
  • Ankara University Affiliated: Yes

Abstract

Objectives: Gene variation in the cholinergic muscarinic receptor 1 (CHRM1) has potential to become a candidate biomarker in the development of several disorders as well as drug response. In this study, a novel polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was developed to determine the C to A single nucleotide polymorphism at position 267 in the CHRM1 gene.