A Novel Genotyping Method for Detection of the Muscarinic Receptor M1 Gene rs2067477 Polymorphism and Its Genotype/Allele Frequencies in a Turkish Population
TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.17, sa.6, ss.653-658, 2020 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 6
- Basım Tarihi: 2020
- Doi Numarası: 10.4274/tjps.galenos.2019.46793
- Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.653-658
- Anahtar Kelimeler: CHRM1, C267A, Turkish, schizophrenia, PCR-RFLP, VARIANT, SCHIZOPHRENIA, EPIDEMIOLOGY, EXPRESSION, COGNITION
- Ankara Üniversitesi Adresli: Evet
Özet
Objectives: Gene variation in the cholinergic muscarinic receptor 1 (CHRM1) has potential to become a candidate biomarker in the development of several disorders as well as drug response. In this study, a novel polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay was developed to determine the C to A single nucleotide polymorphism at position 267 in the CHRM1 gene.