A new benzoxazole compound as antimicrobial agent Anti̇mi̇krobi̇yal etki̇li̇ yeni̇ bi̇r benzoksazol bi̇leşi̇ǧi̇

ARPACI Ö., Kaynak-Onurdaǧ F.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.35, sa.3, ss.189-196, 2006 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 35 Sayı: 3
  • Basım Tarihi: 2006
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.189-196
  • Anahtar Kelimeler: Antimicrobial activity, Benzoxazole
  • Ankara Üniversitesi Adresli: Evet

Özet

In this research, 2-(p-chlorophenoxy)methyl-5-(p-chlorophenoxy) acetamidobenzoxazole was synthesized by condensing of 2,4-diaminophenol with p-chlorophenoxyacetic acid in presence of trimethysilylpolyphosphate ester (PPSE). Its structure was elucidated by using IR, 1H NMR and mass analysis methods. The antimicrobial activity of the compound against some Gram-positive, Gram-negative bacteria and Candida albicans and their isolates were determined. The observed Minimum Inhibitory Concentration (MIC) values of the compound was compared to some antibacterial and antifungal drugs.