A new benzoxazole compound as antimicrobial agent Anti̇mi̇krobi̇yal etki̇li̇ yeni̇ bi̇r benzoksazol bi̇leşi̇ǧi̇
Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.35, sa.3, ss.189-196, 2006 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 3
- Basım Tarihi: 2006
- Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.189-196
- Anahtar Kelimeler: Antimicrobial activity, Benzoxazole
- Ankara Üniversitesi Adresli: Evet
Özet
In this research, 2-(p-chlorophenoxy)methyl-5-(p-chlorophenoxy) acetamidobenzoxazole was synthesized by condensing of 2,4-diaminophenol with p-chlorophenoxyacetic acid in presence of trimethysilylpolyphosphate ester (PPSE). Its structure was elucidated by using IR, 1H NMR and mass analysis methods. The antimicrobial activity of the compound against some Gram-positive, Gram-negative bacteria and Candida albicans and their isolates were determined. The observed Minimum Inhibitory Concentration (MIC) values of the compound was compared to some antibacterial and antifungal drugs.