Evaluation of erythropoiesis by serum transferrin receptor and ferritin in infants aged 0-6 months

ULUKOL B., Tezcan S., Akar N., Gokce H., Cin S.

PEDIATRIC HEMATOLOGY AND ONCOLOGY, cilt.21, sa.4, ss.293-305, 2004 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 21 Sayı: 4
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1080/08880010490440428
  • Dergi Adı: PEDIATRIC HEMATOLOGY AND ONCOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.293-305
  • Anahtar Kelimeler: anemia, ferritin, infant, iron deficiency, serum transferrin receptor, IRON-DEFICIENCY ANEMIA, THALASSEMIA TRAIT, MATERNAL ANEMIA, EARLY-CHILDHOOD, TERM INFANTS, CHILDREN, HEMOGLOBIN, PREGNANCY, DIAGNOSIS, VOLUME
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of this study was to evaluate erythropoiesis in 198 healthy babies aged 0-6 months by determination of their blood count, serum transferrin receptor (STfR), and ferritin levels. Anemia and microcytosis were present in 9% and 13% of the sample, respectively. Microcytosis rate was as high as 45% in 6-month-old babies. In infants with normal blood counts, the values of sTfR/ferritin and sTfR-F index were increasing with the increase of sTfR and decrease of ferritin beginning from 2 months of age. In the 5- to 6-month-old group, sTfR concentrations, sTfR/ferritin ratio, and sTfR-F index were higher in infants with anemia and microcytosis. This research showed a high frequency of iron deficiency detected in otherwise healthy babies. Only problems with early weaning practices were found to be significantly more common in babies with iron deficiency.