Atıf İçin Kopyala
TUNCAY E., Bilginoglu A., Sozmen N. N., Zeydanli E. N., UĞUR M., Vassort G., ...Daha Fazla
CARDIOVASCULAR RESEARCH, cilt.89, sa.3, ss.634-642, 2011 (SCI-Expanded)
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Yayın Türü:
Makale / Tam Makale
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Cilt numarası:
89
Sayı:
3
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Basım Tarihi:
2011
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Doi Numarası:
10.1093/cvr/cvq352
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Dergi Adı:
CARDIOVASCULAR RESEARCH
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Derginin Tarandığı İndeksler:
Science Citation Index Expanded (SCI-EXPANDED), Scopus
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Sayfa Sayıları:
ss.634-642
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Anahtar Kelimeler:
Redox regulation, Intracellular free zinc, Excitation-contraction coupling, Intracellular calcium homeostasis, Cardiomyocyte, CELLULAR ZINC, VENTRICULAR MYOCYTES, ZN2+, METALLOTHIONEIN, RELEASE, HOMEOSTASIS, CA2+, CARDIOMYOCYTES, HEART, ACCUMULATION
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Ankara Üniversitesi Adresli:
Evet
Özet
Aims Zinc exists in biological systems as bound and histochemically reactive free Zn2+. It is an essential structural constituent of many proteins, including enzymes from cellular signalling pathways, in which it functions as a signalling molecule. In cardiomyocytes at rest, Zn2+ concentration is in the nanomolar range. Very little is known about precise mechanisms controlling the intracellular distribution of Zn2+ and its variations during cardiac function.