Intracellular free zinc during cardiac excitation-contraction cycle: calcium and redox dependencies

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TUNCAY E., Bilginoglu A., Sozmen N. N., Zeydanli E. N., UĞUR M., Vassort G., ...Daha Fazla

CARDIOVASCULAR RESEARCH, cilt.89, sa.3, ss.634-642, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 89 Sayı: 3
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1093/cvr/cvq352
  • Dergi Adı: CARDIOVASCULAR RESEARCH
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.634-642
  • Anahtar Kelimeler: Redox regulation, Intracellular free zinc, Excitation-contraction coupling, Intracellular calcium homeostasis, Cardiomyocyte, CELLULAR ZINC, VENTRICULAR MYOCYTES, ZN2+, METALLOTHIONEIN, RELEASE, HOMEOSTASIS, CA2+, CARDIOMYOCYTES, HEART, ACCUMULATION
  • Ankara Üniversitesi Adresli: Evet

Özet

Aims Zinc exists in biological systems as bound and histochemically reactive free Zn2+. It is an essential structural constituent of many proteins, including enzymes from cellular signalling pathways, in which it functions as a signalling molecule. In cardiomyocytes at rest, Zn2+ concentration is in the nanomolar range. Very little is known about precise mechanisms controlling the intracellular distribution of Zn2+ and its variations during cardiac function.