Intracellular free zinc during cardiac excitation-contraction cycle: calcium and redox dependencies
CARDIOVASCULAR RESEARCH, cilt.89, sa.3, ss.634-642, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 89 Sayı: 3
- Basım Tarihi: 2011
- Doi Numarası: 10.1093/cvr/cvq352
- Dergi Adı: CARDIOVASCULAR RESEARCH
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.634-642
- Anahtar Kelimeler: Redox regulation, Intracellular free zinc, Excitation-contraction coupling, Intracellular calcium homeostasis, Cardiomyocyte, CELLULAR ZINC, VENTRICULAR MYOCYTES, ZN2+, METALLOTHIONEIN, RELEASE, HOMEOSTASIS, CA2+, CARDIOMYOCYTES, HEART, ACCUMULATION
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Üniversitesi Adresli: Evet
Özet
Aims Zinc exists in biological systems as bound and histochemically reactive free Zn2+. It is an essential structural constituent of many proteins, including enzymes from cellular signalling pathways, in which it functions as a signalling molecule. In cardiomyocytes at rest, Zn2+ concentration is in the nanomolar range. Very little is known about precise mechanisms controlling the intracellular distribution of Zn2+ and its variations during cardiac function.