Assemblage of drug release modules: Effect of module shape and position in-the assembled systems on floating behavior and release rate

Hascicek C., Rossi A., Colombo P., Massimo G., Strusi O. L., Colombo G.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, cilt.77, sa.1, ss.116-121, 2011 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 77 Sayı: 1
  • Basım Tarihi: 2011
  • Doi Numarası: 10.1016/j.ejpb.2010.11.006
  • Dergi Adı: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.116-121
  • Anahtar Kelimeler: Dome Matrix (R), Clindamycin, Floating dosage form, Drug release modules, DELIVERY SYSTEMS, DOSAGE FORMS, FORMULATION, RETENTION
  • Ankara Üniversitesi Adresli: Evet

Özet

The aim of this work was to study the clindamycin release kinetics from floating delivery systems consisting of two modules assembled in void configuration, according to the modified release technology platform known as Dome Matrix. Two modules differently shaped, i.e., female and male, formulated as swellable matrices and containing clindamycin, were assembled by friction interlocking. Then, by stacking additional female modules without drug on the assembled two-module floating system, modulation of clindamycin release rate and kinetics was attained. The additional modules stacked on the assembled system acted as a transient barrier to clindamycin release from the void configuration. Inertness, dissolution/erosion or swelling behavior characterized their performance as matrices in simulated gastric fluid.