Akademik Veri Yönetim Sistemi
3rd International Gazi Pharma Symposium Series, 8 - 10 Eylül 2021, ss.147
Opioid and alcohol addiction are one of the major health problems. Opioids account for 76%
of deaths involving drug use disorders, while alcohol is responsible for about 3.6% of global
deaths. Opioid antagonists block the effects of psychoactive substances and alcohol acting
on µ, ᴋ, and δ opioid receptor sites by binding competitively to these receptors. Because of
the extensive first-pass metabolism, the bioavailability of this group of active
pharmaceutical substances is low and fluctuations in plasma concentrations occur when
used orally. In addition, oral tablets have been associated with high rates of early
withdrawal from treatment. For all these reasons, it would be advantageous to develop a
dosage form in which the liver is bypassed, a constant plasma concentration can be
achieved, and patients are not burdened with taking medication. In this study, in situ
forming gel systems containing XTZ-21 have been investigated to meet all the requirements
based on a gelling mechanism by solvent exchange. Resomer R 203 S as a biodegradable
polymer and dimethyl sulfoxide, N-methyl pyrrolidone, poly(ethylene glycol) dimethyl ether
(Mn = 250), poly(ethylene glycol) 400, benzyl alcohol, and ethyl heptanoate as solvents,
were used for the preparation of formulations. The optimized formulation was determined
by low burst drug release and controlled release of the drug for one month.