Role of FLT3 in the proliferation and aggressiveness of hepatocellular carcinoma

Aydin M. M., Bayin N. S., ACUN T., Yakicier M. C., AKÇALI K. C.

TURKISH JOURNAL OF MEDICAL SCIENCES, cilt.46, sa.2, ss.572-581, 2016 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 46 Sayı: 2
  • Basım Tarihi: 2016
  • Doi Numarası: 10.3906/sag-1501-173
  • Dergi Adı: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.572-581
  • Anahtar Kelimeler: Fms-like tyrosine kinase, liver cancer, regeneration, invasiveness, tyrosine kinase, RECEPTOR TYROSINE KINASE, HEMATOPOIETIC STEM, OVAL CELLS, INHIBITORS, SORAFENIB, DIFFERENTIATION, PATHOGENESIS, RESISTANCE, TARGETS
  • Ankara Üniversitesi Adresli: Evet

Özet

Background/aim: Previously we showed that Fms-like tyrosine kinase (FLT3) changes its cellular localization upon partial hepatectomy, suggesting a role in liver regeneration. FLT3 was also shown to play an important function in cellular proliferation and activation of PI3K and Ras. Thus, we aimed to investigate the role of FLT3 in hepatocellular tumorigenesis utilizing in vitro and in vivo models.