Surface modification of polymeric nanoparticulate drug carrier systems Poli̇meri̇k nanoparti̇küler i̇laç taşiyici si̇stemlerde yüzey modi̇fi̇kasyonu

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ŞENGEL TÜRK C. T., HASÇİÇEK C.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.38, sa.2, ss.137-154, 2009 (Scopus) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 38 Sayı: 2
  • Basım Tarihi: 2009
  • Doi Numarası: 10.1501/eczfak_0000000522
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus
  • Sayfa Sayıları: ss.137-154
  • Anahtar Kelimeler: Nanoparticulate drug delivery systems, Polymeric nanoparticles, Surface modification agents, Surface modification techniques
  • Ankara Üniversitesi Adresli: Evet

Özet

Surface modification can be defined as the improvement and replacement of the surface properties of nano-sized drug delivery systems. In the field of pharmaceutical technology, surface modification provides several advantages to improve the physicochemical properties and pharmaceutical activities of many nanosized carriers particularly polymeric nanoparticles. The surface properties of the polymeric nanoparticulate drug delivery systems play a key role on the biological behaviour that is shown in the organism. By the modification circulation times are prolonged, especially the accumulation in the tumor tissues is improved to higher levels. In this review, the defination and the advantages of the polymeric nanoparticulate systems, the benefits of surface modification, surface modification techniques and the studies in the pharmaceutical field concerning surface modification are covered.