Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.24, sa.3, ss.111-115, 1996 (Scopus)
Supportive therapy of the patients with SIRS is effective on survival. Inotropic therapy is one of the most important components. Recently dobutamine, as an inotrop, because a popular agent. In this study, we aimed to determine the hemodynamic effects of relatively low dose (5 μg/kg/min) dobutamine infusion. 7 patients with SIRS were included in this study. After invasive hemodynamic monitoring was achieved, systolic, diastolic and mean arterial pressures (SAP, DAP, MAP), heart rate (HR), pulmonary pressures (PASP, PADP, PCWP) and central venous pressure (CVP) were recorded. Cardiac output (CO) was measured by thermodilution. Cardiac index (CI), systemic and pulmonary vascular resistance (SVR, PVR) were calculated. Following baseline measurements dobutamine infusion was started. Assessment of hemodynamic parameters were done at 1, 6, 24 hours after start of infusion. HR, SAP, DAP, MAP, PAP, PCWP, CVP and CO did not change. There was a significant decrease in SVR at 1 hour (p<0.05). Also PVR decreased at 6 hour and was still low at 24 hours after infusion. We concluded that, unless they are hypotensive, dobutamine could be a good choice for the patients with SIRS, due to its role on vascular resistance providing a better organ perfusion and exerting beneficial effects on systemic circulation.