Effect of picroside II on erythrocyte deformability and lipid peroxidation in rats subjected to hind limb ischemia reperfusion injury

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Comu F. M., Kilic Y., ÖZER A., Kirisci M., Dursun A. D., TATAR T., ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.10, pp.927-931, 2016 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10
  • Publication Date: 2016
  • Doi Number: 10.2147/dddt.s95418
  • Journal Name: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.927-931
  • Keywords: hind limb ischemia reperfusion injury, lipid peroxidation, malondialdehyde, nitric oxide, erythrocyte deformability, picroside II, MYOCARDIAL-ISCHEMIA, SKELETAL-MUSCLE, NITRIC-OXIDE, SUPEROXIDE, MODEL
  • Ankara University Affiliated: Yes

Abstract

Background: Ischemia reperfusion injury (I/R) in hind limb is a frequent and important clinical phenomenon. Many structural and functional damages are observed in cells and tissues in these kinds of injuries. In this study, we aimed to evaluate the effect of picroside II on lipid peroxidation and erythrocyte deformability during I/R in rats.