Akademik Veri Yönetim Sistemi
Journal of the Electrochemical Society, cilt.166, sa.12, 2019 (SCI-Expanded)
© 2019 The Electrochemical Society.In the present work, an anti-tuberculosis drug, morphazinamide HCl (MRA) was investigated at ultra-trace level in real sample for the first time. Iron (III) oxide nanoparticles (Fe2O3NPs) were casted on a glassy carbon electrode (GCE) for the determination of MRA. Cyclic voltammetry, electrochemical impedance spectroscopy, transmission electron microscopy, scanning electron microscopy and energy-dispersive X-ray spectroscopy were employed for morphological characterization of the electrode surface. The results displayed a higher surface area and greater conductivity for the Fe2O3NPs modified glassy carbon electrode (Fe2O3NPs/GCE) than bare GCE. The square wave voltammetry response of the Fe2O3NPs/GCE was linear with MRA concentration in the range of 1 μM to 100 μM under optimized conditions (0.1M phosphate buffer solution at pH 3.0; drop-casting volume 10 μL; accumulation time 15 s; accumulation potential -0.3 V), with a detection limit of 0.21 nM. Also, the proposed procedure was very efficient for MRA determination from human serum sample with high recoveries.