HBV X protein: elucidating a role in oncogenesis

Feitelson M. A., Reis H. M. G. P. V., Pan J., Clayton M., Sun B., TUFAN N. L., ...Daha Fazla

FUTURE VIROLOGY, cilt.3, sa.5, ss.455-470, 2008 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 3 Sayı: 5
  • Basım Tarihi: 2008
  • Doi Numarası: 10.2217/17460794.3.5.455
  • Dergi Adı: FUTURE VIROLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.455-470
  • Anahtar Kelimeler: apoptosis, fibrosis, hepatitis B x antigen, hepatocellular carcinoma, senescence, signal transduction, steatosis, treatment, tumor suppressors, HEPATITIS-B-VIRUS, NF-KAPPA-B, ADVANCED HEPATOCELLULAR-CARCINOMA, FAS-MEDIATED APOPTOSIS, HUMAN LIVER-CELLS, GENE-EXPRESSION, FACTOR-ALPHA, UP-REGULATION, TRANSCRIPTIONAL ACTIVITY, TRANSGENIC MICE
  • Ankara Üniversitesi Adresli: Hayır

Özet

Chronic HBV infection is associated with the development of hepatocellular carcinoma (HCC). HBV contributes to tumorigenesis by encoding hepatitis B x antigen (HBxAg), which is a trans-regulatory protein that appears to contribute to HCC by altering patterns of host gene expression. In this review, recent data is presented that outlines some of the putative mechanisms whereby HBxAg contributes to HCC. With the development of animal models of HBxAg-mediated HCC, the relevance and temporal order of putative steps in this process can now be dissected to elucidate what is rate limiting and when. This will have a profound impact on the design of novel and specific therapeutics for HCC.