Synthesis of Co/Co3O4 Heterostructure in N-Doped Porous, Amorphous Carbon: A Superior Electrochemical Sensor for Sensitive Determination of Alectinib in Various Fluids
ACS Omega, cilt.9, sa.44, ss.44282-44292, 2024 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 9 Sayı: 44
- Basım Tarihi: 2024
- Doi Numarası: 10.1021/acsomega.4c04821
- Dergi Adı: ACS Omega
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Directory of Open Access Journals
- Sayfa Sayıları: ss.44282-44292
- Ankara Üniversitesi Adresli: Evet
Özet
Highly crystallized Co and Co3O4 nanoparticles embedded in an N-doped amorphous carbon matrix have been successfully fabricated by the molten-salt-assisted method using KClO3 and zeolitic imidazolate framework-12 (ZIF-12). Pyrolysis of ZIF-12 with different concentrations of KClO3 leads to embedded Co and Co3O4 nanoparticles in a conductive amorphous carbon network. The impact of salt concentration on the morphology and electrochemical performance of these composites was investigated for electrochemical sensor applications. By employing a straightforward and efficient technique, Co/Co3O4 heterostructures were successfully synthesized in N-doped porous amorphous carbon. The Co/Co3O4 carbon heterostructures were optimized by varying the salt concentration, resulting in a significant electrochemical sensor performance for detecting ALC in both bulk and biological fluids. The sensor demonstrates excellent sensitivity (62.97 nmol/L) and selectivity toward ALC, with a wide linear range (0.2-2 μM) and a low detection limit (18.89 nM). Furthermore, it displays remarkable stability and reproducibility, positioning it as a strong contender for practical use in pharmaceutical analysis and biomedical research. This study presents a significant advancement in electrochemical sensing technology and underscores the potential of Co/Co3O4 heterostructures in the development of high-performance sensors for detecting bioactive compounds in complex matrices.