Cognitive Performance Patterns in Healthy Individuals with Substantia Nigra Hyperechogenicity and Early Parkinson's Disease

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Yilmaz R., Graeber S., Roeben B., Suenkel U., von Thaler A., Heinzel S., ...Daha Fazla

FRONTIERS IN AGING NEUROSCIENCE, cilt.8, 2016 (SCI-Expanded, Scopus)

• Yayın Türü: Makale / Tam Makale
• Cilt numarası: 8
• Basım Tarihi: 2016
• Doi Numarası: 10.3389/fnagi.2016.00271
• Dergi Adı: FRONTIERS IN AGING NEUROSCIENCE
• Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
• Anahtar Kelimeler: substantia nigra hyperechogenicity, Parkinson's disease, cognition, transcranial sonography, prodromal Parkinson's disease, TRANSCRANIAL SONOGRAPHY, IMPAIRMENT, DISORDERS, RISK, DIAGNOSIS, SYMPTOMS, MUTATION, INCIDENT, MEMORY
• Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
• Ankara Üniversitesi Adresli: Hayır

Özet

Introduction: Hyperechogenicity of the substantia nigra (SN+) is a risk marker for Parkinson's disease (PD) which can be detected before the diagnosis. In healthy individuals, SN+ has been associated with slight deficits in specific cognitive functions, suggesting cognitive impairment as a possible pre-diagnostic marker for PD. However, the pattern of cognitive deficits associated with SN+ has not yet been compared with those present in PD.