Alkaloids of Sternbergia clusiana and their angalgesic effects

Tanker M., Citoglu G., Gumusel B., Sener B.

International Journal of Pharmacognosy, vol.34, no.3, pp.194-197, 1996 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 34 Issue: 3
  • Publication Date: 1996
  • Journal Name: International Journal of Pharmacognosy
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.194-197
  • Keywords: Analgesic activity, Haemanthidine, Lycorine, Modified Koster's test Amaryllidaceae, Sternbergia clusiana (Ker-Gawl.) Ker Gawl. ex Sprengel
  • Ankara University Affiliated: Yes

Abstract

Sternbergia clusiana of Turkish origin has yielded four alkaloids, lycorine, haemanthamine, haemanthidine, and tazettine. The alkaloids were separated using chromatographic methods and purified by crystalization. Their structures have been elucidated by spectroscopic studies. The analgesic activity of lycorine and haemanthidine was determined using modified Koster's test. Lycorine and haemanthidine showed a significant analgesic effect. The analgesic activities of lycorine and haemanthidine are higher than those of aspirin.