Effect of Probucol on Proliferation of Leukemia, Multiple Myeloma, Lymphoma, and Fibroblast Cells

KOÇ A., KARABAY A. Z., Yaprak A., Buyukbingol Z., AKTAN F.

TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, cilt.18, sa.1, ss.75-79, 2021 (ESCI, Scopus, TRDizin) identifier identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 18 Sayı: 1
  • Basım Tarihi: 2021
  • Doi Numarası: 10.4274/tjps.galenos.2019.04657
  • Dergi Adı: TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES
  • Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, EMBASE, International Pharmaceutical Abstracts, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.75-79
  • Anahtar Kelimeler: Probucol, chronic myeloid leukemia, multiple myeloma, histiocytic lymphoma, acute myeloid leukemia
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: Probucol is a bisphenol antioxidant with antiinflammatory, antilipidemic and antidiabetic effect. Development and progression of cancer is closely related to chronic inflammation and oxidative stress. Agents that target these processes have been shown to modulate cancer cell proliferation. In this regard, the effect of probucol on proliferation of different cancer cell lines was investigated.