Akademik Veri Yönetim Sistemi
Turk Anesteziyoloji ve Reanimasyon, cilt.24, sa.1, ss.24-28, 1996 (Scopus)
In this study the effects of propofol and fentanyl anesthesia on TNF-alpha levels were compared in open cardiac surgery performed on both CPB and on beating heart operations. 40 patients divided into 4 groups were studied. All patients gave informed written consent and the study was approved by the hospital's ethic committee. Blood samples were taken before induction, after induction, after surgical incision, during ischemia, after ischemia and postop. 24 hours. Data analyses were performed by one-way-analysis of Variance (ANOVA) p<0.05 was accepted as statistically significant. No significant difference was observed in TNF-alpha levels between the propofol and fentanyl group. When CPB and beating heart operations were compared there was an increase in TNF-alpha levels both with propofol and fentanyl anesthesia on beating heart operations after the ischemia and postop. 24 hours (p<0.05). It was concluded that fentanyl and propofol didn't change any TNF-alpha level in CPB and beating heart operations but when the groups were compared with respect to the surgical technique it was resulted that surgery on beating heart can cause significant increase in TNF-alpha levels that may contribute to hemodynamic and immunologic responses.