Serum Levels of Interleukin-36 Alpha and Interleukin-36 Receptor Antagonist in Behcet's Syndrome

Creative Commons License

Ünsal P., Çerçi P., Açlkgöz Ş. A., KESKİN G., ÖLMEZ Ü.

Aktuelle Rheumatologie, cilt.47, sa.3, ss.233-238, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 47 Sayı: 3
  • Basım Tarihi: 2022
  • Doi Numarası: 10.1055/a-1550-2069
  • Dergi Adı: Aktuelle Rheumatologie
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE
  • Sayfa Sayıları: ss.233-238
  • Anahtar Kelimeler: Interleukin-36, Immunologie, Pathogenesis, Vasculitis, Behcet's syndrome, Interleukin-36, Studienlage, Pathogenese, Vaskulitis, Behcet-Syndrom, INFLAMMATORY ACTIVITY, RHEUMATOID-ARTHRITIS, CYTOKINE FAMILY, EXPRESSION, IL-36, PATHOGENESIS, IL-1RRP2
  • Ankara Üniversitesi Adresli: Evet

Özet

© 2022. Thieme. All rights reserved.Background Behcet's syndrome (BS) is a systemic vasculitic disorder. This study aimed to investigate the levels of serum IL-36α and IL-36Ra in patients with BS. Material and Methods A total of 80 subjects (60 BS patients and 20 healthy controls [HC]) were included. Results The median IL-36α level was 0.11 ng/ml in the BS group and 0.09 ng/ml in the HC group (p=0.058). The mean IL-36Ra level was 13.62 pg/ml in the BS group and 13.26 pg/ml in the HC group (p=0.348). Serum IL-36Ra levels of the active group were significantly higher (p=0.037). Patients with oral ulcers and central nervous system involvement had higher serum IL36Ra levels. In the BS group, a positive correlation was found between serum IL-36Ra and CRP. In a multivariate analysis, the IL-36Ra level (OR=1.067; 95% CI=1.001-1.137; p=0.045) was independently associated with disease activity. Conclusion According to these findings, it is not clear whether such a slight difference is clinically significant, but they suggest that the IL-36 cytokine family may play a role in the course of the disease.