PERIOPERATIVE NEUROCOGNITIVE DISORDERS IN GERIATRIC PATIENTS: A REVIEW OF NEURONAL PATHOPHYSIOLOGY

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MEÇO B. C., GÜMÜŞ AKAY G.

TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI, cilt.25, sa.2, ss.339-346, 2022 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 25 Sayı: 2
  • Basım Tarihi: 2022
  • Doi Numarası: 10.31086/tjgeri.2022.292
  • Dergi Adı: TURKISH JOURNAL OF GERIATRICS-TURK GERIATRI DERGISI
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, EMBASE
  • Sayfa Sayıları: ss.339-346
  • Anahtar Kelimeler: Neurocognitive Disorders, Perioperative Period, Synapse, Neuroinflammatory Diseases, Geriatrics, POSTOPERATIVE COGNITIVE DYSFUNCTION, GENERAL-ANESTHESIA, REGIONAL ANESTHESIA, DISEASE, SURGERY, INJURY, TRANSMISSION, INHIBITION, PLASTICITY, HALOTHANE
  • Ankara Üniversitesi Adresli: Evet

Özet

Introduction: With the ageing population, elderly patients are overrepresented among surgical patients, and experience an increased variety of postoperative complications. Of these complications, perioperative neurocognitive disorders significantly jeopardize patients' postoperative outcomes. Risk factors for perioperative neurocognitive disorders include age, depth of anesthesia, preoperative cognitive function, and surgical procedure type. However, the underlying pathophysiological mechanisms are still not well understood and have been the focus of multiple previous studies. This narrative review aimed to define the possible pathophysiological pathways of perioperative neurocognitive disorders from different cellular perspectives.