Soluk Tekkeşin M., Sinanoğlu A., Aksakallı F. N.
17th International Congress on Oral Pathology and Medicine Joint Meeting of the British Society for Oral & Maxillofacial Pathology, 23 September 2004 - 30 May 2016, vol.119, no.3, pp.191, (Full Text)
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Publication Type:
Conference Paper / Full Text
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Volume:
119
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Doi Number:
10.1016/j.oooo.2014.07.392
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Page Numbers:
pp.191
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Ankara University Affiliated:
No
Abstract
Objective
Malignant transformation is suggested to be a consequence of alterations in cell cycle control, and this potential of oral lichen planus (OLP) is still controversial. The aim of this study was to evaluate the malignant transformation of OLP comparing with oral squamous cell carcinoma (OSCC) by immunohistochemistry.
Study Design
Bcl-2 and p53 expressions were determined by immunohistochemistry in 100 oral mucosal biopsies including normal oral mucosa (n=20), OLP (n=40) and OSCC (n=40).
Results
There were no significant differences in p53 and bcl-2 expressions between OLP and OSCC cases. However p53 expression was higher in OLP and OSCC compared to normal epithelium (p<0.05).
Conclusions
The results of this study suggest that the expression of these proteins might be an evidence of the potential of malignant transformation process in OLP. Therefore, there is a need for long term follow-up of patients with OLP to detect any malignant alteration.
Keywords
lichen planus, bcl-2, p53, oral squamous cell carcinoma