Effect of picroside II on hind limb ischemia reperfusion injury in rats

Creative Commons License

Kilic Y., ÖZER A., TATAR T., ZOR M. H., Kirisci M., Kartal H., ...More

DRUG DESIGN DEVELOPMENT AND THERAPY, vol.11, pp.1917-1925, 2017 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 11
  • Publication Date: 2017
  • Doi Number: 10.2147/dddt.s132401
  • Journal Name: DRUG DESIGN DEVELOPMENT AND THERAPY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1917-1925
  • Keywords: ischemia reperfusion, picroside II, hind limb skeletal muscle, TOS, TAS, TOTAL ANTIOXIDANT CAPACITY, SKELETAL-MUSCLE, MYOCARDIAL-ISCHEMIA, PICRORHIZA-KURROA, RENAL INJURY, VITAMIN-C, MODEL, LUNG, ILOPROST
  • Ankara University Affiliated: Yes

Abstract

Introduction: Many structural and functional damages are observed in cells and tissues after reperfusion of previously viable ischemic tissues. Acute ischemia reperfusion (I/R) injury of lower extremities occurs especially when a temporary cross-clamp is applied to the abdominal aorta during aortic surgery. Research regarding the treatment of I/R injury has been increasing day-by-day. In this study, we aimed to investigate the effect of picroside II on skeletal muscle of rats experiencing simulated I/R.