Effects of cyclosporine on oxidant/antioxidant status in rat ovary tissues: Protective role of black grape extract

Erguder I., Cetin R., Devrim E., Kilicoglu B., Avci A., Durak I.

INTERNATIONAL IMMUNOPHARMACOLOGY, cilt.5, sa.7-8, ss.1311-1315, 2005 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 5 Sayı: 7-8
  • Basım Tarihi: 2005
  • Doi Numarası: 10.1016/j.intimp.2005.03.016
  • Dergi Adı: INTERNATIONAL IMMUNOPHARMACOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.1311-1315
  • Anahtar Kelimeler: ovary, oxidan/antioxidant status, black grape, CARCINOMA DU145 CELLS, SUPEROXIDE-DISMUTASE, RADICAL METABOLISM, APOPTOTIC DEATH, RESVERATROL, PROANTHOCYANIDINS, HEPATOTOXICITY, KIDNEY, GROWTH
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: It has been demonstrated that immunosuppressive drug cyclosporine A (CsA) increases the synthesis of reactive oxygen species (ROS) and lipid peroxidation products in vitro and in vivo studies, but its possible toxic effects in ovary tissue have not been defined yet. This study was designed to elucidate possible relation between CsA treatment and oxidant/antioxidant status in rat ovary tissue and, to determine if antioxidant supplementation is beneficial.