Investigations on the effect of base and solvents on the elimination of p-toluene sulphonyl group in the synthesis of dehydroalanine

SÜZEN S.

Ankara Universitesi Eczacilik Fakultesi Dergisi, cilt.30, sa.1, ss.17-25, 2001 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 30 Sayı: 1
  • Basım Tarihi: 2001
  • Dergi Adı: Ankara Universitesi Eczacilik Fakultesi Dergisi
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.17-25
  • Anahtar Kelimeler: Beta-elimination, Dehydroamino acid, p-toluenesulfonyl chloride, Serine
  • Ankara Üniversitesi Adresli: Evet

Özet

Dehydroamino acids are constitutents of certain peptide antibiotics and represent an important class of compound. Considerable attention has been given recently to the preparation of dehydroaminoacids, particularly of the dehydroalanine unit, which is generally derived from serine derivatives. In this study the conversion of a serine to a dehydroalanine unit using different base and solvents was investigated using N-benzyloxycarbonyl-O-tosyl derivative of serine.