The relationship between the serotonin 2A receptor gene-1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patients

DEMİRBÜGEN ÖZ, MERVE; UÇKUN, ZUHAL; Yuce-Artun, Nazan; BASKAK, BORA; Ozdemir, Hatice; Ozel, Tugba; ÖZGÜVEN, HALİSE; SÜZEN, HALİT

doi:10.1002/hup.2673

The relationship between the serotonin 2A receptor gene-1438A/G and 102T/C polymorphisms and citalopram/sertraline-induced nausea in major depressed patients

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DEMİRBÜGEN ÖZ M., UÇKUN Z., Yuce-Artun N., BASKAK B., Ozdemir H., Ozel T. K., ...More

HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL, vol.33, no.5, 2018 (SCI-Expanded)

Publication Type: Article / Article
Volume: 33 Issue: 5
Publication Date: 2018
Doi Number: 10.1002/hup.2673
Journal Name: HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
Keywords: citalopram, nausea, polymorphism, serotonin-2A receptor, sertraline, REUPTAKE INHIBITOR, CYP2C19 POLYMORPHISMS, GENE POLYMORPHISM, 3B RECEPTOR, ANTIDEPRESSANT, PHARMACOGENETICS, EFFICACY, ASSOCIATION, METABOLISM, MECHANISMS
Ankara University Affiliated: Yes

Abstract

Objective: The aim of the present study was to determine the relationship between the polymorphisms of -1438A/G and 102T/C in the 5-HT2A receptor (HTR2A) gene and nausea/vomiting as a side effect induced by sertraline (SERT) or citalopram (CIT) in patients with major depressive disorder.