Association Between N363S and Bcl/Polymorphisms of the Glucocorticoid Receptor Gene (NR3C1) and Glucocorticoid Side Effects During Childhood Acute Lymphoblastic Leukemia Treatment

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Cihan M. K., KARABULUT H. G., KUTLAY N., ILGIN RUHİ H., Tukun A., Olcay L.

TURKISH JOURNAL OF HEMATOLOGY, cilt.34, sa.2, ss.151-158, 2017 (SCI-Expanded, Scopus, TRDizin)

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 34 Sayı: 2
  • Basım Tarihi: 2017
  • Doi Numarası: 10.4274/tjh.2016.0253
  • Dergi Adı: TURKISH JOURNAL OF HEMATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.151-158
  • Anahtar Kelimeler: Acute lymphoblastic leukemia, Glucocorticoid receptor gene, BclI and N363S polymorphisms, BODY-MASS INDEX, IN-VIVO, BCLI POLYMORPHISM, MAJOR DEPRESSION, CHILDREN, DISEASE, RESISTANCE, SENSITIVITY, MUTATIONS, THERAPY
  • Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
  • Ankara Üniversitesi Adresli: Evet

Özet

Objective: Glucocorticoids (GCs) are the key drugs for the treatment of pediatric acute lymphoblastic leukemia (ALL). Herein, investigation of the relationship between the N363S and Bcl / polymorphisms of the GC receptor gene (NR3C1) and the side effects of GCs during pediatric ALL therapy was aimed.