Micronization of salicylic acid and taxol (paclitaxel) by rapid expansion of supercritical fluids (RESS)

Yildiz N., Tuna S., Doker O., Calimli A.

JOURNAL OF SUPERCRITICAL FLUIDS, vol.41, no.3, pp.440-451, 2007 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 41 Issue: 3
  • Publication Date: 2007
  • Doi Number: 10.1016/j.supflu.2006.12.012
  • Journal Name: JOURNAL OF SUPERCRITICAL FLUIDS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.440-451
  • Keywords: supercritical fluids, RESS, particle size, salicylic acid, taxol, CARBON-DIOXIDE, CO2, PARTICLES, IBUPROFEN
  • Ankara University Affiliated: Yes

Abstract

The particle sizes of the pharmaceutical substances are important for their bioavailability. The bioavailability can be improved by reducing the particle size of the drug. In this study, salicylic acid and taxol were micronized by the rapid expansion of supercritical fluids (RESS). Supercritical CO2 and CO2 + ethanol mixture were used as solvent. Experiments were carried out to investigate the effect of extraction temperature (318-333 K) and pressure (15-25 MPa), pre-expansion temperature (353-413 K), expansion chamber temperature (273-293 K), spray distance (6-13 cm), cosolvent concentration (ethanol, 1, 2, 3, v/v, %) and nozzle configuration (capillary and orifice nozzle) on the size and morphology of the precipitated salicylic acid particles. For taxol, the effects of extraction pressure (25, 30, 35 MPa) and co-solvent concentration (ethanol, 2, 5, 7, v/v, %) were investigated. The characterization of the particles was determined by scanning electron microscopy (SEM), optical microscopy, and LC-MS analysis.