Is it possible to improve antioxidant activity of curcumin with the structure of lipid-based nanocarriers?


Creative Commons License

AMASYA ÇELİKTEN G., Yedikaya O., BADILLI F. U., ÖZDEMİR A. N.

Journal of Research in Pharmacy, cilt.27, sa.2, ss.566-575, 2023 (Scopus) identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 27 Sayı: 2
  • Basım Tarihi: 2023
  • Doi Numarası: 10.29228/jrp.338
  • Dergi Adı: Journal of Research in Pharmacy
  • Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
  • Sayfa Sayıları: ss.566-575
  • Anahtar Kelimeler: Antioxidant effect, Curcumin, Lipid-based nanocarriers, Nanoemulsions, Nanostructured lipid carriers, Solid lipid nanoparticles
  • Ankara Üniversitesi Adresli: Evet

Özet

Although curcumin is a commonly used antioxidant in cosmetic and pharmaceutical products, the dermal efficacy of curcumin is limited due to its very low solubility and poor permeability. Considering dermal application, lipid-based nanocarriers (LbNs) are highlighted as promising delivery systems for enhancing the efficacy of active substances. The aim of this study is to evaluate the effect of the components of LbNs on the antioxidant activity of curcumin. For this purpose, the mixture of Precirol® ATO5 and Tristearin was selected as solid lipid; while vitamin E, pomegranate seed oil (PSO) and Labrafac® Lipophile WL 1349 were used as liquid lipids. Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsion (NE) formulations were designed by using different combination of these lipids and Gelucire®50/13 as an amphiphilic surfactant. The particle size, PDI, zeta potential analysis, encapsulation efficiency and in-vitro release studies were performed as particle characteristics. The contribution of LbNs with different structures to the antioxidant capacity of curcumin was evaluated by in-vitro ABTS scavenging experiment. While SLN has an average particle size of 106.7 nm with negative zeta potential, the size of NLC and NE formulations were below 100nm. The highest curcumin release upon 24h was obtained by NLC formulation prepared with PSO. A significant contribution to the antioxidant activity of curcumin was obtained when vitamin E and PSO were used as liquid lipid in NLC and NE formulations. In conclusion, it is possible to improve the antioxidant effect of curcumin by the modification of the structure of LbNs.