Synthesis and in vitro antioxidant activity of new pyrimidin/benzothiazol-substituted piperazinyl flavones

Kladna A., Berczynski P., BOZDAĞ DÜNDAR O., UEnluesoy M., Sari E., Bakinowska B., ...More

FUTURE MEDICINAL CHEMISTRY, vol.10, no.19, pp.2293-2308, 2018 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 10 Issue: 19
  • Publication Date: 2018
  • Doi Number: 10.4155/fmc-2018-0206
  • Journal Name: FUTURE MEDICINAL CHEMISTRY
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2293-2308
  • Keywords: antioxidant activity, chemiluminescence, free radical inhibitory activity, piperazinyl flavone analogs, spectroscopy, DNA-BINDING, SCAVENGING ACTIVITY, OXIDATIVE STRESS, GLUTAMIC-ACID, DERIVATIVES, SUPEROXIDE, CANCER, THALIDOMIDE, CHEMISTRY, CAPACITY
  • Ankara University Affiliated: Yes

Abstract

Aim: Synthesis of novel 2(2-hydroxyphenyl) pyrimidine/benzothiazole piperazinyl-substituted flavones end evaluate their antioxidant activity. Results: Six novel 2-(2-hydroxyphenyl) pyrimidine/benzothiazole-substituted flavones were synthesized, their structures were confirmed by elementary and spectral analyses. The compounds were evaluated for their in vitro antioxidant potency by employing various antioxidant assays. Conclusion: All tested compounds acted as scavengers of free radicals like hydroxyl (15-45%),2,2-diphenyl-1-picrylhydrazyl(center dot) (17-48%) at 1.25 and 0.5mM concentrations respectively. The total antioxidant status activity values of the compounds ranged from 234.1 to 464.1m trolox equivalent/g, the total antioxidant capacity - from 24.9 to 52.7m trolox equivalent per gram. Compounds incorporating the benzothiazole group on the piperazine ring were more effective antioxidants than those with the 2-(2-hydroxyphenyl) pyrimidine group.