Synthesis and in vitro antioxidant activity of new pyrimidin/benzothiazol-substituted piperazinyl flavones

Kladna A., Berczynski P., BOZDAĞ DÜNDAR O., UEnluesoy M., Sari E., Bakinowska B., ...Daha Fazla

FUTURE MEDICINAL CHEMISTRY, cilt.10, sa.19, ss.2293-2308, 2018 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 10 Sayı: 19
  • Basım Tarihi: 2018
  • Doi Numarası: 10.4155/fmc-2018-0206
  • Dergi Adı: FUTURE MEDICINAL CHEMISTRY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.2293-2308
  • Anahtar Kelimeler: antioxidant activity, chemiluminescence, free radical inhibitory activity, piperazinyl flavone analogs, spectroscopy, DNA-BINDING, SCAVENGING ACTIVITY, OXIDATIVE STRESS, GLUTAMIC-ACID, DERIVATIVES, SUPEROXIDE, CANCER, THALIDOMIDE, CHEMISTRY, CAPACITY
  • Ankara Üniversitesi Adresli: Evet

Özet

Aim: Synthesis of novel 2(2-hydroxyphenyl) pyrimidine/benzothiazole piperazinyl-substituted flavones end evaluate their antioxidant activity. Results: Six novel 2-(2-hydroxyphenyl) pyrimidine/benzothiazole-substituted flavones were synthesized, their structures were confirmed by elementary and spectral analyses. The compounds were evaluated for their in vitro antioxidant potency by employing various antioxidant assays. Conclusion: All tested compounds acted as scavengers of free radicals like hydroxyl (15-45%),2,2-diphenyl-1-picrylhydrazyl(center dot) (17-48%) at 1.25 and 0.5mM concentrations respectively. The total antioxidant status activity values of the compounds ranged from 234.1 to 464.1m trolox equivalent/g, the total antioxidant capacity - from 24.9 to 52.7m trolox equivalent per gram. Compounds incorporating the benzothiazole group on the piperazine ring were more effective antioxidants than those with the 2-(2-hydroxyphenyl) pyrimidine group.