Electrochemical development of poly(L alanine) gold nanoparticles modified electrode for the determination and mechanism of antipsychotic drug olanzapine

Tüzün Ü. N., Yıldız C., Eskiköy Bayraktepe D., Polat K., Yazan Z.

PBA2023, 33rd International Symposium on Pharmaceutical and Biomedical Analysis, Ankara, Türkiye, 2 - 06 Temmuz 2023, ss.125-126

  • Yayın Türü: Bildiri / Yayınlanmadı
  • Basıldığı Şehir: Ankara
  • Basıldığı Ülke: Türkiye
  • Sayfa Sayıları: ss.125-126
  • Ankara Üniversitesi Adresli: Evet

Özet

A novel electrochemical sensor for sensitive determination of antipsychotic drug efficient matter olanzapine (OLA) was introduced in the current research. The fabricated sensor was based on pre-treated pencil graphite electrode (pre-PGE) modified with poly(L-alanine) and gold nanoparticles (AuNPs). The effect of monomer L-alanine and chloroauric acid concentrations, pH, and scan rate was tested with differential pulse voltammetry (DPV) and cyclic voltammetry (CV). The analytical method validation parameters were studied. The linear response of OLA was in the ranges of (0.271-1000.0) µM with the correlation coefficient 0.99. LOD and LOQ were found to be 0.081 µM, and 0.271 µM, respectively. The interference effect was investigated for fluoxetine (FLX), ascorbic acid (AA), uric acid (UA), acetaminophen (APAP), sodium (Na+), potassium (K+), calcium (Ca2+), and magnesium (Mg2+) cations. The utility of AuNPs-poly(L-alanine)/pre-PGE sensor was worked for the determination of OLA in its pharmaceutical dosage form, human serum, and human urine. Finally, the probable electrochemical oxidation mechanism of the OLA was suggested.

Keywords: Poly(L-alanine), gold nanoparticles, pencil graphite electrode, olanzapine, voltammetry, electrooxidation mechanism.