Significance of immunohistochemical markers in women with breast cancer
Nigerian journal of clinical practice, vol.26, no.3, pp.314-318, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 26 Issue: 3
- Publication Date: 2023
- Doi Number: 10.4103/njcp.njcp_252_22
- Journal Name: Nigerian journal of clinical practice
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, EMBASE, MEDLINE
- Page Numbers: pp.314-318
- Keywords: Breast cancer, immunohistochemical markers, molecular subtypes
- Ankara University Affiliated: Yes
Abstract
Background and Aims: This study aimed to investigate the importance of immunohistochemical (IHC) markers and other prognostic variables in the definition of breast cancer. Patients and Methods: Two hundred female patients who underwent breast cancer surgery were classified into two groups according to age: young women (≤45 years; n = 104) and older women (≥65 years; n = 96). Molecular subtypes and local stages were determined. The Kaplan-Meier method was used to estimate the survival curves. The relationships among categorical variables were analyzed using the Chi-square test. Results: The difference between the tumor diameter and distribution of Ki-67 levels was significant (P = 0.001, P < 0.05). T stage, local stage, histological grade, estrogen receptor status, lymphovascular invasion status, axillary nodal state, human epidermal growth factor receptor 2 status, and distribution of molecular subtypes were correlated (P < 0.05). The mean disease-free survival rates (DFS) at 1, 2, and 5 years were found 92.9%, 86.5%, and 70.1%, respectively, in the young female group. The DFS rates of older patients were 96.7%, 95.4%, and 84.6%, respectively. Conclusion: This study showed that young age was associated with poor prognostic features at the IHC marker level.