Cranial bone regeneration via BMP-2 encoding mesenchymal stem cells
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, cilt.45, sa.3, ss.544-550, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 45 Sayı: 3
- Basım Tarihi: 2017
- Doi Numarası: 10.3109/21691401.2016.1160918
- Dergi Adı: ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.544-550
- Anahtar Kelimeler: Bone morphogenetic protein-2, cranial bone regeneration, critical size defect, mesenchymal stem cell, transfection, MORPHOGENETIC PROTEIN-2, GROWTH-FACTOR, IN-VIVO, SCAFFOLDS, CRYOGELS, DEFECTS
- Ankara Üniversitesi Adresli: Hayır
Özet
Cranial bone repair and regeneration via tissue engineering principles has attracted a great deal of interest from researchers during last decade. Here, within this study, 6mm critical-sized bone defect regeneration via genetically modified mesenchymal stem cells (MSC) were monitored up to 4 months. Cranial bone repair and new bone formations were evaluated by histological staining and real time PCR analysis in five different groups including autograft and bone morphogenetic protein-2 (BMP-2) transfected MSC groups. Results presented here indicate a proper cranial regeneration in autograft groups and a prospering regeneration for hBMP-2 encoding mesenchymal stem cells.