In Vitro Evaluation of Accuracy of CBCT-Derived Volumes in Maxillary Defects: Effects of kVp, Device, and Software


MURAT S., KAMBUROĞLU K., Vazquez D., Nart L. J., Azcona V., Benitez L. E., ...Daha Fazla

Diagnostics, cilt.15, sa.10, 2025 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 15 Sayı: 10
  • Basım Tarihi: 2025
  • Doi Numarası: 10.3390/diagnostics15101247
  • Dergi Adı: Diagnostics
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, EMBASE, INSPEC, Directory of Open Access Journals
  • Anahtar Kelimeler: computer-assisted, cone-beam computed tomography, image processing, volume measurement, X-ray microtomography
  • Ankara Üniversitesi Adresli: Evet

Özet

Objectives: This study aimed to evaluate the accuracy of CBCT-based volumetric measurements of maxillary defects and to investigate the effects of different CBCT devices, kVp settings, and segmentation software on measurement accuracy. Methods: CBCT images from eight patients with maxillary defects were used to generate 3D-printed models for volumetric assessment. Two CBCT systems (Largev Smart and Planmeca Promax) were evaluated at three different kVp settings. Volume calculations were conducted using ITK-SNAP version 4.2.2 and 3D Doctor version 4.0 software, while micro-CT served as the gold standard (GS) for comparison. Statistical analysis included a three-way ANOVA to assess the effect of CBCT parameters and software on volumetric accuracy. Additionally, post-hoc Tukey HSD analysis was performed to identify specific differences between kVp groups, and Pearson correlation analysis was used to evaluate consistency with the GS. Significance level was set at p < 0.05. Results: Higher kVp settings significantly improved volumetric accuracy, with 100 kVp yielding the smallest deviations (−3.77%) from the GS. Tukey HSD analysis revealed significant differences between 60–80 kVp (p = 0.008), 60–100 kVp (p < 0.001), and 80–100 kVp (p = 0.041), confirming the influence of kVp on accuracy. No significant differences were observed between CBCT devices or software programs (p > 0.05). A strong positive correlation (r = 0.96) between CBCT-derived and micro-CT volumes confirmed CBCT’s reliability for volumetric assessments (p < 0.001). Conclusions: CBCT provides accurate volumetric measurements of maxillary defects, particularly at higher kVp settings. These findings support its clinical application for preoperative planning and postoperative evaluation, offering a cost-effective alternative to micro-CT.