The involvement of apoptotic regulators during in vitro decidualization

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AKÇALI K. C., Gibori G., Khan S.

EUROPEAN JOURNAL OF ENDOCRINOLOGY, cilt.149, sa.1, ss.69-75, 2003 (SCI-Expanded) identifier identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 149 Sayı: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1530/eje.0.1490069
  • Dergi Adı: EUROPEAN JOURNAL OF ENDOCRINOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.69-75
  • Ankara Üniversitesi Adresli: Hayır

Özet

Objectives: The uterus responds to an implanting blastocyst by undergoing extensive tissue modification leading to decidualization. This modification includes differentiation and apoptosis of epithelial as well as stromal cell compartments. It is generally accepted that the decidual cell regression pattern is similar to the pattern of initial differentiation, suggesting that decidual cell death is the end point of timed differentiation. However, the molecular mechanisms controlling these events are not understood clearly. Therefore, we aimed to investigate the involvement of apoptotic factors using an in vitro cell culture system.