Mucoadhesive microspheres containing gentamicin sulfate for nasal administration: Preparation and in vitro characterization

HASÇİÇEK C., Gönül N., ERK N.

Farmaco, cilt.58, sa.1, ss.11-16, 2003 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 58 Sayı: 1
  • Basım Tarihi: 2003
  • Doi Numarası: 10.1016/s0014-827x(02)00004-6
  • Dergi Adı: Farmaco
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, International Pharmaceutical Abstracts
  • Sayfa Sayıları: ss.11-16
  • Anahtar Kelimeler: Gentamicin sulfate, Hydroxypropyl methylcellulose, Mucoadhesive microspheres, Nasal drug delivery, Sodium cholate, Spray drying
  • Ankara Üniversitesi Adresli: Evet

Özet

In this study, suitable microsphere formulations were designed in order to provide the absorption of a high polar drug through nasal mucosa. For this purpose, gentamicin sulfate (GS) was chosen as a model drug and used at different drug/polymer ratios in the microsphere formulations. The microspheres were prepared by spray drying technique. Hydroxypropyl methylcellulose was used as a mucoadhesive polymer in the formulations to increase the residence time of the microspheres on the mucosa. Sodium cholate was added into the formulations for increasing the absorption of GS through nasal mucosa. The in vitro characteristics of the microspheres were determined. The microspheres were evaluated with respect to the particle size, production yield, encapsulation efficiency, shape and surface properties, drug-polymer interaction, mucoadhesive property, in vitro drug release and suitability for nasal drug delivery. © 2003 Éditions scientifiques et médicales Elsevier SAS. All rights reserved.