Efficacy of hepatitis B vaccination and interferon-alpha-2b combination therapy versus interferon-alpha-2b monotherapy in children with chronic hepatitis B

Helvaci M., Kizilgunesler A., Kasirga E., Ozbal E., KUZU M. A., Sozen G.

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, cilt.19, sa.7, ss.785-791, 2004 (SCI-Expanded) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 19 Sayı: 7
  • Basım Tarihi: 2004
  • Doi Numarası: 10.1111/j.1440-1746.2004.03358.x
  • Dergi Adı: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
  • Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Sayfa Sayıları: ss.785-791
  • Anahtar Kelimeler: children, hepatitis B virus, interferon, vaccine, IMMUNOTOLERANT PHASE, IMMUNOTHERAPY, INFECTION, MANAGEMENT, RESPONSES, ANTIGENS, ALPHA
  • Ankara Üniversitesi Adresli: Evet

Özet

Background: Although interferon (IFN) has been approved in the treatment of chronic hepatitis B in children, it is effective only in 30-40% of patients. In some studies it has been suggested that therapeutic use of anti-hepatitis B virus (HBV) vaccine may be beneficial in patients with chronic hepatitis B. The aim of the present study was to compare the efficacy of hepatitis B vaccination and IFN-alpha-2b in combination and IFN-alpha-2b monotherapy in children with chronic hepatitis B.