Ratio-spectra zero-crossing derivative spectrophotometric determination of certain drugs in two-component mixtures

Erk N.

ANALYTICAL LETTERS, vol.32, no.7, pp.1371-1388, 1999 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 32 Issue: 7
  • Publication Date: 1999
  • Doi Number: 10.1080/00032719908542904
  • Journal Name: ANALYTICAL LETTERS
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.1371-1388
  • Keywords: two component mixtures, simultaneous determination, ratio-spectra zero-crossing derivative spectrophotometric, pharmaceutical formulations, PERFORMANCE LIQUID-CHROMATOGRAPHY, UV SPECTROPHOTOMETRY, HYDROCHLOROTHIAZIDE, TABLETS, HYDROCHLORIDE, FORMULATIONS, COMBINATION
  • Ankara University Affiliated: No

Abstract

Two two-component mixtures have been assayed using both Vierordt's method and ratio-spectra zero-crossing derivative spectrophotometric methods. Such mixtures are hydrochlorothiazide-spironolactone and hydrochlorothiazide-ramipril. These selected applications illustrate the relative ease and simplicity offered by ratio - spectra zero-crossing derivative spectrophotometry for the assay of two component mixtures with spectral interferences from matrix formulations.